Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy

Q Sun, Z Wang, B Liu, F He, S Gai, P Yang… - Coordination Chemistry …, 2022 - Elsevier
In view of certain unique internalization features of the tumor microenvironment
(TME)(mainly including hypoxia, acidity and higher concentrations of H 2 O 2 and GSH) …

Inflammation-responsive drug-loaded hydrogels with sequential hemostasis, antibacterial, and anti-inflammatory behavior for chronically infected diabetic wound …

Y Wang, Y Wu, L Long, L Yang, D Fu… - … applied materials & …, 2021 - ACS Publications
Stimuli-responsive hydrogels possess unique advantages in drug delivery due to their
variable performance and status based on the external environment. In the present study, a …

A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing

Y Wu, Y Wang, L Long, C Hu, Q Kong… - Journal of Controlled …, 2022 - Elsevier
Fabricating injectable hydrogel with multifunctions that matchs the highly ordered healing
process of skin regeneration has greatly desired in treatment of chronic diabetic wounds …

Molecular bottlebrush prodrugs as mono-and triplex combination therapies for multiple myeloma

A Detappe, HVT Nguyen, Y Jiang, MP Agius… - Nature …, 2023 - nature.com
Cancer therapies often have narrow therapeutic indexes and involve potentially suboptimal
combinations due to the dissimilar physical properties of drug molecules. Nanomedicine …

Responsive hydrogel dressings for intelligent wound management

S Wang, WY Wu, JCC Yeo, XYD Soo, W Thitsartarn… - …, 2023 - Wiley Online Library
Due to global aging problems, the rising number of patients suffering from chronic or hard‐to‐
heal acute wounds imposes a significant burden on healthcare systems. Wound healing is a …

Reactive oxygen species (ROS)-responsive prodrugs, probes, and theranostic prodrugs: applications in the ROS-related diseases

P Wang, Q Gong, J Hu, X Li… - Journal of Medicinal …, 2020 - ACS Publications
Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …

Multistage ROS-responsive and natural polyphenol-driven prodrug hydrogels for diabetic wound healing

Z Ni, H Yu, L Wang, Y Huang, H Lu… - ACS applied materials …, 2022 - ACS Publications
The high level of reactive oxygen species (ROS) and bacterial infection impede wound
healing of the diabetic wound. Here, benefiting from the antioxidation effects of tannic acid …

Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing

C Hu, F Zhang, L Long, Q Kong, R Luo… - Journal of controlled …, 2020 - Elsevier
Disease microenvironment stimuli-responsive hydrogels are of special interests in
enhancing the drug delivery specificity for biomedical applications. In order to achieve …

Polymeric Nanoparticles for Drug Delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …