General anesthetics have been used to ablate consciousness during surgery for more than
150 years. Despite significant advances in our understanding of their molecular-level …

New Hypnotic Drug Development and Pharmacologic Considerations for Clinical Anesthesia -
Anesthesiology Clinics Skip to Main Content Skip to Main Menu Advertisement Log in Register …

A robust three-step continuous flow procedure is presented for the efficient and sustainable
preparation of active pharmaceutical ingredient ketamine. The procedure relies on the main …

Drug discovery is the cornerstone of developments in the field of anesthesia. Each year, new
drugs enter the market and possibly change clinical practice. The development of new …

BACKGROUND: Ketamine is a well-established, rapidly acting dissociative anesthetic.
Clinical use is limited by prolonged psychotomimetic phenomena on emergence, often …

Ketamine [2-(2-chlorophenyl)-2-(methylamino) cyclohexanone] is a dissociative anaesthetic,
first developed in 1963 by Parke-Davis. It finds widespread application in the treatment of …

Despite 50 years of clinical use and experimental endeavor the anesthetic, analgesic, and
psychomimetic effects of ketamine remain to be fully elucidated. While NMDA receptor …

N-Aliphatic ester analogues of the non-opioid ketamine (1) retain effective
anaesthetic/analgesic properties while minimising ketamine's psychomimetic side-effects …

Herein, we report the synthesis of aryl derivatives of ketamine and of ketamine's major
metabolites hydroxynorketamine (HNK), norketamine (NK), and dehydronorketamine …

Depression is a chronic, severe, and often life-threatening neurological disorder. It not only
causes depression in patients and affects daily life but, in severe cases, may lead to suicidal …