Digital holographic deep learning of red blood cells for field-portable, rapid COVID-19 screening

T O'Connor, JB Shen, BT Liang, B Javidi - Optics Letters, 2021 - opg.optica.org
Rapid screening of red blood cells for active infection of COVID-19 is presented using a
compact and field-portable, 3D-printed shearing digital holographic microscope. Video …

Deep learning-based cell identification and disease diagnosis using spatio-temporal cellular dynamics in compact digital holographic microscopy

T O'Connor, A Anand, B Andemariam… - Biomedical Optics …, 2020 - opg.optica.org
We demonstrate a successful deep learning strategy for cell identification and disease
diagnosis using spatio-temporal cell information recorded by a digital holographic …

Quantitative dynamic evolution of physiological parameters of RBC by highly stable digital holographic microscopy

M Kumar, O Matoba, X Quan, SK Rajput… - Optics and Lasers in …, 2022 - Elsevier
Digital holographic microscopy (DHM) is a powerful label-free imaging tool that provides
three-dimensional (3D) quantitative information of a specimen. In this work, the evaluation of …

COVID-19 detection from red blood cells using highly comparative time-series analysis (HCTSA) in digital holographic microscopy

T O'Connor, S Santaniello, B Javidi - Optics Express, 2022 - opg.optica.org
We present an automated method for COVID-19 screening based on reconstructed phase
profiles of red blood cells (RBCs) and a highly comparative time-series analysis (HCTSA) …

COVID-19 screening with digital holographic microscopy using intra-patient probability functions of spatio-temporal bio-optical attributes

T O'Connor, B Javidi - Biomedical Optics Express, 2022 - opg.optica.org
We present an automated method for COVID-19 screening using the intra-patient population
distributions of bio-optical attributes extracted from digital holographic microscopy …

Assaying storage lesion of irradiated red blood cells by deep learning with attention mechanism

C Zhang, J Wang, W Sun, D Peng, YD Wang… - Optics and Lasers in …, 2024 - Elsevier
In blood transfusion, irradiation of red blood cells (RBCs) is a widely used treatment method.
The storage lesion of RBCs has a significant impact on patient prognosis. How to rapidly …

No-search focus prediction at the single cell level in digital holographic imaging with deep convolutional neural network

K Jaferzadeh, SH Hwang, I Moon… - Biomedical optics …, 2019 - opg.optica.org
Digital propagation of an off-axis hologram can provide the quantitative phase-contrast
image if the exact distance between the sensor plane (such as CCD) and the reconstruction …

Biomechanics of ex vivo-generated red blood cells investigated by optical tweezers and digital holographic microscopy

C Bernecker, MARBF Lima, CD Ciubotaru, P Schlenke… - Cells, 2021 - mdpi.com
Ex vivo-generated red blood cells are a promising resource for future safe blood products,
manufactured independently of voluntary blood donations. The physiological process of …

Quantitative analysis of three-dimensional morphology and membrane dynamics of red blood cells during temperature elevation

K Jaferzadeh, MW Sim, NG Kim, IK Moon - Scientific Reports, 2019 - nature.com
The optimal functionality of red blood cells is closely associated with the surrounding
environment. This study was undertaken to analyze the changes in membrane profile, mean …

Quantitative phase imaging by wide-field interferometry with variable shearing distance uncoupled from the off-axis angle

R Guo, SK Mirsky, I Barnea, M Dudaie, NT Shaked - Optics express, 2020 - opg.optica.org
We introduce a new shearing interferometry module for digital holographic microscopy, in
which the off-axis angle, which defines the interference fringe frequency, is not coupled to …