Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Modular polyketide synthases (PKSs) run catalytic reactions over dozens of steps in a highly
orchestrated manner. To accomplish this synthetic feat, they form megadalton multienzyme …

Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

Covering: 2008 up to 2019 The forces of biochemical adaptive evolution operate at the level
of genes, manifesting in complex phenotypes and the global biodiversity of proteins and …

Covering: mid 1990s to 2018 Over the last two decades, diverse approaches have been
explored to generate new polyketides by engineering polyketide synthases (PKSs) …

Re-engineering biosynthetic assembly lines, including nonribosomal peptide synthetases
(NRPS) and related megasynthase enzymes, is a powerful route to new antibiotics and other …

Next to plants, bacteria account for most of the biomass on Earth. They are found
everywhere, although certain species thrive only in specific ecological niches. These …

Nonribosomal peptides (NRP) are crucial molecular mediators in microbial ecology and
provide indispensable drugs. Nevertheless, the evolution of the flexible biosynthetic …