New antimicrobial strategies based on metal complexes

M Claudel, JV Schwarte, KM Fromm - Chemistry, 2020 - mdpi.com
Traditional organic antimicrobials mainly act on specific biochemical processes such as
replication, transcription and translation. However, the emergence and wide spread of …

Triazole derivatives and their anti-tubercular activity

S Zhang, Z Xu, C Gao, QC Ren, L Chang, ZS Lv… - European journal of …, 2017 - Elsevier
Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases,
threats one-third of the world's population. Although numerous efforts have been undertaken …

Metal complexes as a promising source for new antibiotics

A Frei, J Zuegg, AG Elliott, M Baker, S Braese… - Chemical …, 2020 - pubs.rsc.org
There is a dire need for new antimicrobial compounds to combat the growing threat of
widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting …

Emerging impact of triazoles as anti-tubercular agent

A Sharma, AK Agrahari, S Rajkhowa… - European Journal of …, 2022 - Elsevier
Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

Recent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes

CB Scarim, RL de Farias, AV de Godoy Netto… - European Journal of …, 2021 - Elsevier
Metal-based drugs are privileged motifs that act as primary pharmacophores in bioactive
compounds for various diseases, including tuberculosis (TB). This potentially life-threatening …

Platinum (II) and Ruthenium (II) complexes in medicine: Antimycobacterial and Anti-HIV activities

DM Yufanyi, HS Abbo, SJJ Titinchi, T Neville - Coordination Chemistry …, 2020 - Elsevier
Approximately 100 million people worldwide are affected by M. Tuberculosis (Mtb), a
contagious disease which causes death in humans and is considered to be quite deadly …

[HTML][HTML] A comprehensive approach to the analysis of antibiotic-metal complexes

S Ramotowska, M Wysocka, J Brzeski… - TrAC Trends in …, 2020 - Elsevier
Complexes of antibiotics with metal ions draw attention of scientists looking for new drugs as
well as those endeavoring to increase the activity of antibiotics that are currently in use. The …

Metal–peptide complexes as promising antibiotics to fight emerging drug resistance: New perspectives in tuberculosis

C Di Natale, I De Benedictis, A De Benedictis… - Antibiotics, 2020 - mdpi.com
In metal-peptide interactions, cations form stable complexes through bonds with
coordinating groups as side chains of amino acids. These compounds, among other things …

[HTML][HTML] Thiazole, triazole, thio-and semicarbazone derivatives-Promising moieties for drug development for the treatment of tuberculosis

CB Scarim, FR Pavan - European Journal of Medicinal Chemistry Reports, 2021 - Elsevier
Thiazole, triazole, thio and semicarbazones are privileged motifs that act as
pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB) …

Synthesis and antiplasmodial activity of novel indoleamide derivatives bearing sulfonamide and triazole pharmacophores

N Devender, S Gunjan, R Tripathi… - European Journal of …, 2017 - Elsevier
Due to the recent reports of growing parasite resistance to artemisinins and other
antimalarial drugs, development of new antimalarial chemotypes is an urgent priority. Here …