[HTML][HTML] Cyclophilin inhibition as potential therapy for liver diseases
NV Naoumov - Journal of hepatology, 2014 - Elsevier
The cyclophilins are a group of proteins with peptidyl-prolyl isomerase enzymatic activity,
localised in different cellular compartments and involved in a variety of functions related to …
localised in different cellular compartments and involved in a variety of functions related to …
[HTML][HTML] Cyclophilins and cyclophilin inhibitors in nidovirus replication
AH de Wilde, U Pham, CC Posthuma, EJ Snijder - Virology, 2018 - Elsevier
Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase
activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several …
activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several …
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A
L Coelmont, X Hanoulle, U Chatterji, C Berger… - PloS one, 2010 - journals.plos.org
DEB025/Debio 025 (Alisporivir) is a cyclophilin (Cyp)-binding molecule with potent anti-
hepatitis C virus (HCV) activity both in vitro and in vivo. It is currently being evaluated in …
hepatitis C virus (HCV) activity both in vitro and in vivo. It is currently being evaluated in …
One atom makes all the difference: getting a foot in the door between SOS1 and KRAS
J Ramharter, D Kessler, P Ettmayer… - Journal of Medicinal …, 2021 - ACS Publications
KRAS, the most common oncogenic driver in human cancers, is controlled and signals
primarily through protein–protein interactions (PPIs). The interaction between KRAS and …
primarily through protein–protein interactions (PPIs). The interaction between KRAS and …
Molecular nature and regulation of the mitochondrial permeability transition pore (s), drug target (s) in cardioprotection
The mitochondrial permeability transition, an established mechanism for heart diseases, is a
long-standing mystery of mitochondrial biology and a prime drug target for cardioprotection …
long-standing mystery of mitochondrial biology and a prime drug target for cardioprotection …
Domain 3 of NS5A protein from the hepatitis C virus has intrinsic α-helical propensity and is a substrate of cyclophilin A
D Verdegem, A Badillo, JM Wieruszeski… - Journal of Biological …, 2011 - ASBMB
Nonstructural protein 5A (NS5A) is essential for hepatitis C virus (HCV) replication and
constitutes an attractive target for antiviral drug development. Although structural data for its …
constitutes an attractive target for antiviral drug development. Although structural data for its …
Treatment with a triazole inhibitor of the mitochondrial permeability transition pore fully corrects the pathology of sapje zebrafish lacking dystrophin
A Stocco, N Smolina, P Sabatelli, J Šileikytė… - Pharmacological …, 2021 - Elsevier
High-throughput screening identified isoxazoles as potent but metabolically unstable
inhibitors of the mitochondrial permeability transition pore (PTP). Here we have studied the …
inhibitors of the mitochondrial permeability transition pore (PTP). Here we have studied the …
Efficacy and safety of alisporivir for the treatment of hepatitis C infection
C Stanciu, A Trifan, C Muzica… - Expert Opinion on …, 2019 - Taylor & Francis
ABSTRACT Introduction: Alisporivir (ALV)(previously known as Debio 025) is a potent,
pangenotypic host-targeting antiviral oral agent acting on cyclophilin A, which is necessary …
pangenotypic host-targeting antiviral oral agent acting on cyclophilin A, which is necessary …
[PDF][PDF] Alisporivir plus ribavirin, interferon free or in combination with pegylated interferon, for hepatitis C virus genotype 2 or 3 infection
JM Pawlotsky, R Flisiak, SK Sarin, J Rasenack… - …, 2015 - Wiley Online Library
Alisporivir is a cyclophilin inhibitor with pan‐genotypic anti–hepatitis C virus (HCV) activity
and a high barrier to viral resistance. The VITAL‐1 study assessed alisporivir as interferon …
and a high barrier to viral resistance. The VITAL‐1 study assessed alisporivir as interferon …
[PDF][PDF] Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin)
A Kuglstatter, F Mueller, E Kusznir, B Gsell… - … Section D: Biological …, 2011 - journals.iucr.org
E-ISA247 (voclosporin) is a cyclosporin A analogue that is in late-stage clinical development
for the treatment of autoimmune diseases and the prevention of organ graft rejection. The X …
for the treatment of autoimmune diseases and the prevention of organ graft rejection. The X …