Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …

The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …

Genome-wide association analysis advanced understanding of blood pressure (BP), a
major risk factor for vascular conditions such as coronary heart disease and stroke …

Atherosclerotic coronary artery disease (CAD) comprises a broad spectrum of clinical
entities that include asymptomatic subclinical atherosclerosis and its clinical complications …

Abstract Objective Canonical Wnt/β-catenin signaling is a well-studied endogenous
regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and …

Cardiovascular disease (CVD) and cancer are leading causes of mortality and morbidity
worldwide. Strategies to improve their treatment and prevention are global priorities and …

Metabolic syndrome (MetS) is a cluster ofassociated metabolic traits that collectively confer
unsurpassed risk for development of cardiovascular disease (CVD) and type 2 diabetes …

The involvement of cardiovascular disease in cancer onset and development represents a
contemporary interest in basic science. It has been recognized, from the most recent …

The role of the Wnt signaling pathway in metabolic homeostasis has drawn our intensive
attention, especially after the genome-wide association study discovery that certain …