The B cell receptor (BCR) and its precursor (pre-BCR) control B cell homeostasis,
differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central …

Highlights•Quantitative measurements of 40 proteins or mRNA species per cell.•Antibodies
labeled with isotopes instead of fluorophores.•Deep cell profiling of functional network …

Purpose Survival and progression of mature B-cell malignancies depend on signals from the
B-cell antigen receptor, and Bruton tyrosine kinase (BTK) is a critical signaling kinase in this …

Certain malignant B cells rely on B-cell receptor (BCR)–mediated survival signals. Spleen
tyrosine kinase (Syk) initiates and amplifies the BCR signal. In in vivo analyses of B-cell …

BTK is a kinase that functions downstream of multiple receptors in various hematologic cells.
This review focuses on BTK-dependent pathways that are likely to be involved in …

The role of B-cell receptor (BCR)–mediated survival signals in diffuse large B-cell lymphoma
(DLBCL) remains undefined. Ligand-induced BCR signaling induces receptor …

Introduction The aim was to determine the effect of the Bruton tyrosine kinase (Btk)-selective
inhibitor PCI-32765, currently in Phase I/II studies in lymphoma trials, in arthritis and immune …

SYK (spleen tyrosine kinase) is well-characterized in the immune system as an essential
enzyme required for signaling through multiple classes of immune recognition receptors. As …

Bruton agammaglobulinemia tyrosine kinase (BTK), a cytoplasmic protein tyrosine kinase, is
a component of the B-cell receptor signaling pathway. Ibrutinib, a BTK inhibitor, has …

Histologic transformation (HT) to an aggressive lymphoma is a well-described event in the
natural history and clinical course of patients with so-called indolent lymphomas. This …