Ageing is a complex process that negatively impacts the development of the immune system
and its ability to function. The mechanisms that underlie these age‐related defects are broad …

Hematopoiesis arguably provides the most well-defined role of stem cells in tissue
development, maintenance, and repair, largely because of the experimental methods …

The traditional view of hematopoiesis has been that all the cells of the peripheral blood are
the progeny of a unitary homogeneous pool of hematopoietic stem cells (HSCs). Recent …

Anticancer chemotherapy drugs challenge hematopoietic tissues to regenerate but
commonly produce long-term sequelae. Chemotherapy-induced deficits in hematopoietic …

The increasing ratio of ageing population poses new challenges to healthcare systems. The
elderly frequently suffer from severe infections. Vaccination could protect them against …

Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …

The aryl hydrocarbon receptor (AhR) is known mainly as the mediator for the toxicity of
certain xenobiotics. However, there is also much information to indicate that this transcription …

Loss of immune function and increased hematopoietic disease are among the most clinically
significant consequences of aging. Hematopoietic stem cells (HSCs) from mice lacking aryl …

OBJECTIVE: To test function of hematopoietic stem cells (HSCs) in vivo in C57BL/6 (B6) and
Trp53-deficient (Trp53 null) mice by using two HSC enrichment schemes. MATERIALS AND …

Many reports have revealed the importance of the sympathetic nervous system (SNS) in the
control of the bone marrow environment. However, the specific role of neuropeptide Y (NPY) …