▪ Abstract Cardiomyopathies are primary disorders of cardiac muscle associated with
abnormalities of cardiac wall thickness, chamber size, contraction, relaxation, conduction …

Factors that render patients with cardiovascular disease at high risk for heart failure remain
incompletely defined. Recent insights into molecular genetic causes of myocardial diseases …

Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be
caused by mutations in sarcomere proteins. Clinical diagnosis depends on an abnormal …

Cardiovascular disorders are the leading cause of morbidity and mortality in the developed
world, and hypertrophic cardiomyopathy (HCM) is among the most frequently occurring …

Hypertrophic (HCM) and dilated (DCM) cardiomyopathies are inherited diseases with a high
incidence of death due to electric abnormalities or outflow tract obstruction. In many of the …

Hypertrophic cardiomyopathy (HCM) affects more than 1 in 500 people in the general
population with an extensive burden of morbidity in the form of arrhythmia, heart failure, and …

Sixteen years ago, mutations in cardiac troponin (Tn) T and α-tropomyosin were linked to
familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β …

Hypertrophic Cardiomyopathy (HCM) is a relatively common primary cardiac disorder
defined as the presence of a hypertrophied left ventricle in the absence of any other …

Purpose To evaluate myocardial strain and circumferential transmural strain difference
(cTSD; the difference between epicardial and endocardial circumferential strain) in a …

We hypothesize that age-related skeletal muscle dysfunction and physical disability may be
partially explained by alterations in the function of the myosin molecule. To test this …