Voltage-gated potassium channels as therapeutic targets

H Wulff, NA Castle, LA Pardo - Nature reviews Drug discovery, 2009 - nature.com
The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Neural KCNQ (Kv7) channels

DA Brown, GM Passmore - British journal of pharmacology, 2009 - Wiley Online Library
KCNQ genes encode five Kv7 K+ channel subunits (Kv7. 1–Kv7. 5). Four of these (Kv7. 2–
Kv7. 5) are expressed in the nervous system. Kv7. 2 and Kv7. 3 are the principal molecular …

[HTML][HTML] Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment

MM Goldenberg - Pharmacy and Therapeutics, 2010 - ncbi.nlm.nih.gov
Epilepsy is a chronic medical disorder or condition, usually resulting in unpredictable,
unprovoked recurrent seizures that affect a variety of mental and physical functions. It is one …

Molecular basis for ligand activation of the human KCNQ2 channel

X Li, Q Zhang, P Guo, J Fu, L Mei, D Lv, J Wang, D Lai… - Cell research, 2021 - nature.com
The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is
an important drug target to treat epilepsy, pain and several other diseases related to …

[HTML][HTML] Opening paths to novel analgesics: the role of potassium channels in chronic pain

C Tsantoulas, SB McMahon - Trends in neurosciences, 2014 - cell.com
Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …

[HTML][HTML] Potassium channels in behavioral brain disorders. Molecular mechanisms and therapeutic potential: a narrative review.

KA Alam, P Svalastoga, A Martinez, JC Glennon… - Neuroscience & …, 2023 - Elsevier
Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

K+ Channel Modulators for the Treatment of Neurological Disorders and Autoimmune Diseases

H Wulff, BS Zhorov - Chemical reviews, 2008 - ACS Publications
Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

Potassium channels in epilepsy

R Köhling, J Wolfart - Cold Spring Harbor …, 2016 - perspectivesinmedicine.cshlp.org
This review attempts to give a concise and up-to-date overview on the role of potassium
channels in epilepsies. Their role can be defined from a genetic perspective, focusing on …

Potassium channels in peripheral pain pathways: expression, function and therapeutic potential

X Du, N Gamper - Current neuropharmacology, 2013 - ingentaconnect.com
Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …

Conditional deletions of epilepsy-associated KCNQ2 and KCNQ3 channels from cerebral cortex cause differential effects on neuronal excitability

H Soh, R Pant, JJ LoTurco… - Journal of …, 2014 - Soc Neuroscience
KCNQ2 and KCNQ3 potassium channels have emerged as central regulators of pyramidal
neuron excitability and spiking behavior. However, despite an abundance of evidence …