Taking advantage of the recent development of genetically-defined photo-activatable
actuator molecules, cellular functions, including gene expression, can be controlled by …

Understanding mechanisms of nutrient allocation in organisms requires precise knowledge
of the spatiotemporal dynamics of small molecules in vivo. Genetically encoded sensors are …

Coordination of cellular activity through Ca2+ enables β cells to secrete precise quantities of
insulin. To explore how the Ca2+ response is orchestrated in space and time, we implement …

In general, animal behavior can be described as the neuronal-driven sequence of
reoccurring postures through time. Most of the available current technologies focus on offline …

The mapping of neural circuits activated during behavior down to individual neurons is
crucial for decoding how the brain processes information. Technologies allowing activity …

Navigation through complex environments requires motor planning, motor preparation, and
the coordination between multiple sensory–motor modalities. For example, the stepping …

Emerging genetically-encoded Ca2+-indicators (GECIs) are intensiometric reporters that
increase in fluorescence when bound to Ca2+; highly suited for studying calcium-signaling …

The theory of engrams, proposed several years ago, is highly crucial to understanding the
progress of memory. Although it significantly contributes to identifying new treatments for …

Chromophore‐bearing proteins that are (reversibly) altered after light illumination are major
functional components of nature. They gained considerable attention in the last decades …

The lipid phosphatase PTEN (phosphatase and tensin homologue on chromosome 10) is a
key tumour suppressor gene and an important regulator of neuronal signalling. PTEN …