Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …

Hypomyelinating leukodystrophies constitute a subset of genetic white matter disorders
characterized by a primary lack of myelin deposition. Most patients with severe …

Myelin water imaging is a quantitative neuroimaging technique that provides the myelin
water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular …

Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Quantitative magnetic resonance imaging (MRI) techniques are powerful tools for the study
of human tissue, but, in practice, their utility has been limited by lengthy acquisition times …

Background The g-ratio, quantifying the comparative thickness of the myelin sheath
encasing an axon, is a geometrical invariant that has high functional relevance because of …

Purpose The multi‐exponential T2 decay of the MRI signal from cerebral white matter can be
separated into short T2 components related to myelin water and long T2 components related …

Background Myelin specific imaging techniques to characterize white matter in
demyelinating diseases such as multiple sclerosis (MS) have become an area of increasing …

Magnetic resonance imaging (MRI) of focal or diffuse myelin damage or remyelination may
provide important insights into disease progression and potential treatment efficacy in …

Leukodystrophies constitute a large and heterogeneous group of genetic diseases primarily
affecting the white matter of the central nervous system. Different disorders target different …