Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for
mitochondrial division or fission and subsequently determined to mediate human …

Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Purpose To evaluate effectiveness of elamipretide in Barth syndrome (BTHS), a genetic
condition of defects in TAZ, which causes abnormal cardiolipin on the inner mitochondrial …

Cardiovascular disease is the most common cause of death worldwide and in particular,
ischemic heart disease holds the most considerable position. Even if it has been deeply …

Mitochondria are vital organelles with a multifaceted role in cellular bioenergetics,
biosynthesis, signaling and calcium homeostasis. During oxidative phosphorylation, sperm …

Oxidative phosphorylation (OXPHOS) occurs through and across the inner mitochondrial
membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by …

Cardiovascular diseases (CVD) including acute myocardial infarction (AMI) rank first in
worldwide mortality and according to the World Health Organization (WHO), they will stay at …

Mitochondrial defects are one of the common underlying causes of neuronal vulnerability in
neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), and TDP-43 …

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as
nonalcoholic fatty liver disease (NAFLD), encompasses a range of liver conditions from …

Regulating cardiolipin to maintain mitochondrial homeostasis is a promising strategy for
addressing Parkinson's disease (PD). Through a comprehensive screening and validation …