Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

Recently, adeno-associated virus (AAV)-mediated gene therapies have attracted clinical
interest for treating neurodegenerative diseases including spinal muscular atrophy (SMA) …

Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …

Microglia have emerged as a critical component of neurodegenerative diseases. Genetic
manipulation of microglia can elucidate their functional impact in disease. In neuroscience …

Adeno-associated viral (AAV) vectors are a promising system for transgene delivery into the
central nervous system (CNS) based on their safety profile and long-term gene expression …

Introduction: Adeno-associated viral (AAV) vector-mediated gene delivery to the spinal cord
has finally entered the pathway towards regulatory approval. Phase 1 clinical trials using …

Several studies suggest that glial scars pose as physical and chemical barriers that limit
neurite regeneration after spinal cord injury (SCI). Evidences suggest that the activation of …

Microglia are the immune sentinels of the central nervous system with protective roles such
as the removal of neurotoxic oxidized phosphatidylcholines (OxPCs). As aging alters …

Regenerative approaches have made such a great progress, now aiming toward replacing
the exact neurons lost upon injury or neurodegeneration. Transplantation and direct …

Parkinson's disease (PD) is the second most common neurodegenerative disorder in the
aging population and is characterized by a constellation of motor and non-motor symptoms …