The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …

Expected and observed effects of volume exclusion on the free energy of rigid and flexible
macromolecules in crowded and confined systems, and consequent effects of crowding and …

Marina V. Rodnina is the winner of the 2015 Hans Neurath Award. Abstract The cellular
proteome is shaped by the combined activities of the gene expression and quality control …

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major
virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and …

A unifying concept that combines the basic features governing self-organization of proteins
into complex three-dimensional structures in vitro and in vivo is still lacking. Recent …

The geometry of the polypeptide exit tunnel has been determined using the crystal structure
of the large ribosomal subunit from Haloarcula marismortui. The tunnel is a component of a …

In recent years significant effort has been devoted to exploring the potential effects of
macromolecular crowding on protein folding and association phenomena. Theoretical …

Proteins are increasingly used in basic and applied biomedical research. Many proteins,
however, are only marginally stable and can be expressed in limited amounts, thus …

As the nascent polypeptide chain is being synthesized, it passes through a tunnel within the
large ribosomal subunit and emerges at the solvent side where protein folding occurs …

The distances over which biological molecules and their complexes can function range from
a few nanometres, in the case of folded structures, to millimetres, for example, during …