Comparative review of Francisella tularensis and Francisella novicida

LC Kingry, JM Petersen - Frontiers in cellular and infection …, 2014 - frontiersin.org
Francisella tularensis is the causative agent of the acute disease tularemia. Due to its
extreme infectivity and ability to cause disease upon inhalation, F. tularensis has been …

Mechanisms of Francisella tularensis intracellular pathogenesis

J Celli, TC Zahrt - Cold Spring Harbor …, 2013 - perspectivesinmedicine.cshlp.org
Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …

In vivo negative selection screen identifies genes required for Francisella virulence

DS Weiss, A Brotcke, T Henry… - Proceedings of the …, 2007 - National Acad Sciences
Francisella tularensis subverts the immune system to rapidly grow within mammalian hosts,
often causing tularemia, a fatal disease. This pathogen targets the cytosol of macrophages …

A comprehensive transposon mutant library of Francisella novicida, a bioweapon surrogate

LA Gallagher, E Ramage, MA Jacobs… - Proceedings of the …, 2007 - National Acad Sciences
Francisella tularensis, the causative agent of tularemia, is one of the most infectious
bacterial pathogens known and is a category A select agent. We created a sequence …

Production of outer membrane vesicles and outer membrane tubes by Francisella novicida

WD McCaig, A Koller, DG Thanassi - Journal of bacteriology, 2013 - Am Soc Microbiol
Francisella spp. are highly infectious and virulent bacteria that cause the zoonotic disease
tularemia. Knowledge is lacking for the virulence factors expressed by Francisella and how …

The Francisella Pathogenicity Island

FE Nano, C Schmerk - Annals of the New York Academy of …, 2007 - Wiley Online Library
The Francisella pathogenicity island (FPI) is a cluster of 16–19 genes, which is found
duplicated in most of the Francisella genomes that have been sequenced. Although 16 FPI …

Intracellular biology and virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophages

TD Wehrly, A Chong, K Virtaneva… - Cellular …, 2009 - Wiley Online Library
The highly infectious bacterium Francisella tularensis is a facultative intracellular pathogen,
whose virulence requires proliferation inside host cells, including macrophages. Here we …

Working toward the Future: Insights into Francisella tularensis Pathogenesis and Vaccine Development

RD Pechous, TR McCarthy… - … and molecular biology …, 2009 - Am Soc Microbiol
Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

Francisella tularensis: unravelling the secrets of an intracellular pathogen

PCF Oyston - Journal of medical microbiology, 2008 - microbiologyresearch.org
Francisella tularensis has been recognized as the causative agent of tularaemia for almost a
century. Since its discovery in 1911, it has been shown to infect a wide range of hosts …

Genome-Wide Identification of Francisella tularensis Virulence Determinants

J Su, J Yang, D Zhao, TH Kawula, JA Banas… - Infection and …, 2007 - Am Soc Microbiol
Francisella tularensis is a gram-negative pathogen that causes life-threatening infections in
humans and has potential for use as a biological weapon. The genetic basis of the F …