Epithelial tubes are a fundamental tissue across the metazoan phyla and provide an
essential functional component of many of the major organs. Recent work in flies and …

▪ Abstract Many organs including the mammalian lung and vascular system consist of
branched tubular networks that transport essential gases or fluids, but the genetic programs …

SALL4, a human homolog to Drosophila spalt, is a novel zinc finger transcriptional factor
essential for development. We cloned SALL4 and its isoforms (SALL4A and SALL4B) …

Branching morphogenesis involves the restructuring of epithelial tissues into complex and
organized ramified tubular networks. Early rounds of branching are controlled genetically in …

Many organs are composed of tubular networks that arise by branching morphogenesis in
which cells bud from an epithelium and organize into a tube,,. Fibroblast growth factors …

During development, signalling by members of the Notch family of cell surface receptors
plays a widespread role in the assignation of cell fates within the process of lateral inhibition …

The tracheal system of insects is a network of epithelial tubules that functions as a
respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs …

Formins are involved in a wide range of cellular processes that require the remodeling of the
actin cytoskeleton. Here, we have analyzed a novel Drosophila formin, belonging to the …

Identifying the signals involved in maintaining stem cells is critical to understanding stem cell
biology and to using stem cells in future regenerative medicine. In the Drosophila ovary …

This FlyBook chapter summarizes the history and the current state of our understanding of
the Wingless signaling pathway. Wingless, the fly homolog of the mammalian Wnt …