Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

Behavioural, cellular and molecular studies have revealed significant effects of enriched
environments on rodents and other species, and provided new insights into mechanisms of …

Significance: A vast amount of circumstantial evidence implicates high energy oxidants and
oxidative stress as mediators of secondary damage associated with traumatic brain injury …

Background: This review summarizes promising approaches for the treatment of traumatic
brain injury (TBI) that are in either preclinical or clinical trials. Objective: The …

The brain's life-long capacity for experience-dependent plasticity allows adaptation to new
environments or to changes in the environment, and to changes in internal brain states such …

A crucial issue in neurobiology is to understand the main mechanisms restricting neural
plasticity to brief windows of early postnatal life. The visual system is one of the paradigmatic …

Object To examine the influence of deep brain stimulation on hippocampal neurogenesis in
an adult rodent model. Methods Rats were anesthetized and treated for 1 hour with electrical …

Stroke is devastating as currently no therapies are available that can prevent stroke-induced
neurological dysfunction in humans. With the recent observations that acute insults to adult …

Environmental enrichment (EE) results in improved learning and spatial memory, as well as
attenuates morphological changes resulting from cerebral ischemia in adult animals. This …

Chronic stress decreases neurogenesis in the adult brain, while exposure to enriched
environment (EE) increases it. Recent studies demonstrate the ability of EE to ameliorate …