The regulation of mRNA degradation is critical for proper gene expression. Many major
pathways for mRNA decay involve the removal of the 5′ 7-methyl guanosine (m7G) cap in …

The bacterial Hfq protein is a versatile modulator of RNA function and is particularly
important for regulation mediated by small non-coding RNAs. Hfq is a bacterial Sm protein …

Dysregulation of messenger RNA (mRNA) processing—in particular mRNA splicing—is a
hallmark of cancer. Compared to normal cells, cancer cells frequently present aberrant …

The decay of mRNAs is a key step in eukaryotic gene expression. The cytoplasmic Lsm1-7-
Pat1 complex is a conserved component of the 5′-to-3′ mRNA decay pathway, linking …

Hfq and other Sm proteins are central in RNA metabolism, forming an evolutionarily
conserved family that plays key roles in RNA processing in organisms ranging from archaea …

The serine peptidase CLPP is conserved among bacteria, chloroplasts, and mitochondria. In
humans and mice, its loss causes Perrault syndrome, which presents with growth deficits …

Abstract The evolutionarily conserved Lsm1-7-Pat1 complex is the most critical activator of
mRNA decapping in eukaryotic cells and plays many roles in normal decay, AU-rich element …

The cellular environment contains numerous ribonucleases that are dedicated to process
mRNA transcripts that have been targeted for degradation. Here, we review the three …

Solution-based NMR spectroscopy has been an important tool for studying the structure and
dynamics of relatively small proteins and protein complexes with aggregate molecular …

NMR spectroscopy is unique as it provides a means to study bio-molecules with atomic
resolution in a near natural environment. Traditionally, NMR spectroscopic analysis of …