Novel target for treating Alzheimer's Diseases: Crosstalk between the Nrf2 pathway and autophagy

W Zhang, C Feng, H Jiang - Ageing research reviews, 2021 - Elsevier
Abstract In mammals, the Keap1-Nrf2-ARE pathway (henceforth,“the Nrf2 pathway”) and
autophagy are major intracellular defence systems that combat oxidative damage and …

The journey of boswellic acids from synthesis to pharmacological activities

EA Ragab, MF Abd El-Wahab, AS Doghish… - Naunyn-schmiedeberg's …, 2024 - Springer
There has been a lot of interest in using naturally occurring substances to treat a wide
variety of chronic disorders in recent years. From the gum resin of Boswellia serrata and …

Exploring pharmacological active ingredients of traditional Chinese medicine by pharmacotranscriptomic map in ITCM

S Tian, J Zhang, S Yuan, Q Wang, C Lv… - Briefings in …, 2023 - academic.oup.com
With the emergence of high-throughput technologies, computational screening based on
gene expression profiles has become one of the most effective methods for drug discovery …

Nrf2/HO-1 signaling activator acetyl-11-keto-beta Boswellic acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-induced experimental model of ALS

E Minj, S Upadhayay, S Mehan - Neurochemical research, 2021 - Springer
Methylmercury (MeHg) is a potent neurotoxin that causes neurotoxicity and neuronal cell
death. MeHg exposure also leads to oligodendrocyte destruction, glial cell overactivation …

[HTML][HTML] Mechanistic role of boswellic acids in Alzheimer's disease: Emphasis on anti-inflammatory properties

A Siddiqui, Z Shah, RN Jahan, I Othman… - Biomedicine & …, 2021 - Elsevier
The resin/gum of Boswellia species belonging to the family of Burseraceae is a naturally
occurring mixture of bioactive compounds, which was traditionally used as a folk medicine to …

Therapeutic potential of natural products in inflammation: Underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives

NA Gouda, SO Alshammari, MAS Abourehab… - …, 2023 - Springer
Chronic inflammation is a common underlying factor in many major diseases, including
heart disease, diabetes, cancer, and autoimmune disorders, and is responsible for up to …

The role of chronic inflammation in various diseases and anti‐inflammatory therapies containing natural products

RX Wang, M Zhou, HL Ma, YB Qiao, QS Li - ChemMedChem, 2021 - Wiley Online Library
Chronic inflammation represents a long‐term reaction of the body's immune system to
noxious stimuli. Such a sustained inflammatory response sometimes results in lasting …

Nrf2/HO-1 signaling stimulation through acetyl-11-keto-beta-boswellic acid (AKBA) provides neuroprotection in ethidium bromide-induced experimental model of …

S Upadhayay, S Mehan, A Prajapati, P Sethi, M Suri… - Genes, 2022 - mdpi.com
Multiple sclerosis (MS) is a severe immune-mediated neurological disease characterized by
neuroinflammation, demyelination, and axonal degeneration in the central nervous system …

GR-mediated anti-inflammation of α-boswellic acid: Insights from in vitro and in silico studies

J Zhang, J Zhao, Y Sun, Y Liang, J Zhao, H Zou… - Food and Chemical …, 2021 - Elsevier
Although multiple bioactivities of α-boswellic acid have been reported, the molecular
mechanism of its anti-inflammatory action is not yet clear. Hence, glucocorticoid receptor …

Molecular evidences on anti‐inflammatory, anticancer, and memory‐boosting effects of frankincense

M Khajehdehi, M Khalaj‐Kondori… - Phytotherapy …, 2022 - Wiley Online Library
Chemical diversity of natural products with drug‐like features has attracted much attention
from medicine to develop more safe and effective drugs. Their anti‐inflammatory, antitumor …