Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein,
which is overexpressed manifold on prostate cancer as well as neovasculature of most of …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

Ca2+ is an essential ion in all organisms, where it plays a crucial role in processes ranging
from the formation and maintenance of the skeleton to the temporal and spatial regulation of …

Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and
pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell …

All cells possess long-term, steady-state voltage gradients across the plasma membrane.
These transmembrane potentials arise from the combined activity of numerous ion channels …

TRP cation channels display an extraordinary assortment of selectivities and activation
mechanisms, some of which represent previously unrecognized modes for regulating ion …

TRP channel proteins constitute a large and diverse family of proteins that are expressed in
many tissues and cell types. This family was designated TRP because of a spontaneously …

The progression of cells from a normal differentiated state in which rates of proliferation and
apoptosis are balanced to a tumorigenic and metastatic state involves the accumulation of …

The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in
human cancers. Despite increasing interest of pharmacological research in developing …

Identifying regions of the human genome that have been targets of natural selection will
provide important insights into human evolutionary history and may facilitate the …