Despite the fact that MRI has evolved to become the standard method for diagnosis and
monitoring of patients with brain tumours, conventional MRI sequences have two key …

The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …

Inflammation is a highly dynamic and complex adaptive process to preserve and restore
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …

The inducible expression of the mitochondrial translocator protein 18 kDa (TSPO) by
activated microglia is a prominent, regular feature of acute and chronic-progressive brain …

Routine diagnostics and treatment monitoring of brain tumors is usually based on contrast-
enhanced MRI. However, the capacity of conventional MRI to differentiate tumor tissue from …

Schizophrenia is considered a syndrome comprised by several disease phenotypes,
covering a range of underlying pathologies. One of these disease mechanisms seems to …

Objective The 18-kDa mitochondrial translocator protein (TSPO) was reported to be
upregulated in gliomas. 18 F-GE-180 is a novel 3rd generation TSPO receptor ligand with …

Despite numerous clinical trials and pre-clinical developments, the treatment of glioblastoma
(GB) remains a challenge. The current survival rate of GB averages one year, even with an …

Gliomas are highly dynamic and heterogeneous tumours of the central nervous system
(CNS). They constitute the most common neoplasm of the CNS and the second most …

Background PET represents a valuable tool for glioma imaging. In addition to amino acid
tracers such as 18 F-FET, PET targeting the 18-kDa mitochondrial translocator-protein …