Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research

FRS Passos, HG Araújo-Filho, BS Monteiro… - Phytomedicine, 2022 - Elsevier
Background Saponins are glycosides which, after acid hydrolysis, liberate sugar (s) and an
aglycone (sapogenin) which can be triterpenoid or steroidal in nature. Steroidal saponins …

[HTML][HTML] Hecogenin and its derivates: A pharmacology review

MA da Hora Borges, FRS Passos, JSS Quintans… - Biomedicine & …, 2023 - Elsevier
Despite the several uses of drugs from natural compounds in the pharmaceutical industry,
new molecules have been discovered and associated with pharmacological activities over …

Evaluation of the antibacterial activity of hecogenin acetate and its inhibitory potential of NorA and MepA efflux pumps from Staphylococcus aureus

NJS Araújo, ARP da Silva, M do Socorro Costa… - Microbial …, 2023 - Elsevier
Antimicrobial drugs are of great importance in the control of bacterial infections. Its
indiscriminate use contributes to the consolidation of bacterial resistance. Its applicability is …

[HTML][HTML] Analysis of antioxidant, cytotoxic and mutagenic potential of Agave sisalana Perrine extracts using Vero cells, human lymphocytes and mice polychromatic …

RP Araldi, MO Dos Santos, FF Barbon… - Biomedicine & …, 2018 - Elsevier
Brazilian Northeast is the world's largest producer of Agave sisalana Perrine for the supply
of the sisal fiber. About 95% of plant biomass, which comprise the mucilage and sisal juice …

Role of peripheral and central sensitization in the anti-hyperalgesic effect of hecogenin acetate, an acetylated sapogenin, complexed with β-cyclodextrin: involvement …

FRS Passos, EWM Pereira, L Heimfarth, BS Monteiro… - …, 2021 - Elsevier
Neuropathic pain develops due to injury to the somatosensory system, affecting the patient's
quality of life. In view of the ineffectiveness of the current pharmacotherapy, substances …

Synthesis and evaluation of novel thiosemicarbazone and semicarbazone analogs with both anti-proliferative and anti-metastatic activities against triple negative …

C Bai, S Wu, S Ren, M Zhu, G Luo, H Xiang - Bioorganic & Medicinal …, 2021 - Elsevier
Triple-negative breast cancer (TNBC) is one of the most aggressive cancer with high
mortality and recurrence rates. Hecogenin, a steroidal sapogenin, is reported as a potential …

Integrated Metabolite and Transcriptome Profiling-Mediated Gene Mining of Sida cordifolia Reveals Medicinally Important Genes

D Padmanabhan, P Natarajan, S Palanisamy - Genes, 2022 - mdpi.com
Sida cordifolia is a medicinal shrub that is conventionally used in the Indian system of
medicine; however, the genes contributing to its medicinal properties have been minimally …

In vitro evaluation of the susceptibility of bacterial biofilms to hecogenin acetate

NJS Araújo, M do Socorro Costa, ARP da Silva… - Acta Tropica, 2024 - Elsevier
Biofilms are a bacterial resistance strategy through which microorganisms organize
themselves in the form of a colony fixed to a surface that is protected by a polymer matrix …

[HTML][HTML] Computational investigation of Y. aloifolia variegate as anti-Human Immunodeficiency Virus (HIV) targeting HIV-1 protease: A multiscale in-silico exploration

RAP Irsal, GM Gholam, MA Dwicesaria… - Pharmacological …, 2024 - Elsevier
Abstract Introduction Human Immunodeficiency Virus (HIV) is a global challenge for the
health sector due to the absence of a definitive cure. More than 38 million people are …

Spiro compounds: A brief history

M Meazza - Spiro compounds: synthesis and applications, 2022 - Wiley Online Library
The enormous interest in spiro compounds rely on their distinctive properties often
associated with the three‐dimensional stereochemical features, reflecting on their …