It is now widely accepted, given the current weight of experimental evidence, that reactive
oxygen species (ROS) contribute to cell and tissue dysfunction and damage caused by …

The pancreatic duodenum homeobox-1 (PDX-1) is a transcription factor encoded by a Hox-
like homeodomain gene that plays a crucial role in pancreatic development, β-cell …

The endocrine cells of the rat pancreatic islets of Langerhans, including insulin-producing β-
cells, turn over every 40–50 days by processes of apoptosis and the proliferation and …

Oxidative stress is produced under diabetic conditions and is likely involved in progression
of pancreatic β-cell dysfunction found in diabetes. Possibly caused by low levels of …

Considerable progress has been made in the understanding of the sequential activation of
signal transduction pathways and the expression of transcription factors during pancreas …

Aims/hypothesis. Glucagon-like peptide-1 is a potent glucoincretin hormone and a
potentially important drug in the treatment of Type II (non-insulin-dependent) diabetes …

Oxidative stress, which is found in pancreatic β-cells in the diabetic state, suppresses insulin
gene transcription and secretion, but the signaling pathways involved in the β-cell …

The specialized endocrine and exocrine cells of the pancreas originally derive from a pool of
apparently identical cells in the early gut endoderm. Serial changes in their gene expression …

Abstract The C1/RIPE3b1 (− 118/− 107 bp) binding factor regulates pancreatic-β-cell-
specific and glucose-regulated transcription of the insulin gene. In the present study, the …

Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose
sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver …