Rutin as a potent antioxidant: Implications for neurodegenerative disorders

AB Enogieru, W Haylett, DC Hiss… - Oxidative medicine …, 2018 - Wiley Online Library
A wide range of neurodegenerative diseases (NDs), including Alzheimer's disease,
Parkinson's disease, Huntington's disease, and prion diseases, share common mechanisms …

The protective effects of rutin on the liver, kidneys, and heart by counteracting organ toxicity caused by synthetic and natural compounds

S Rahmani, K Naraki, A Roohbakhsh… - Food science & …, 2023 - Wiley Online Library
Rutin is a flavonoid present in many plant species. Because of its antioxidant, anti‐
inflammatory, and antiapoptotic properties, rutin is of interest for its potential protective …

Rutin: A Potential Antiviral for Repurposing as a SARS-CoV-2 Main Protease (Mpro) Inhibitor

PK Agrawal, C Agrawal… - Natural Product …, 2021 - journals.sagepub.com
Various computational studies, including in silico ones, have identified several existing
compounds that could serve as effective inhibitors of the SARS-CoV-2 main protease …

Neuroprotective effect of rutin against colistin-induced oxidative stress, inflammation and apoptosis in rat brain associated with the CREB/BDNF expressions

H Çelik, FM Kandemir, C Caglayan, S Özdemir… - Molecular biology …, 2020 - Springer
The purpose of the current study was to examine the neuroprotective effect of rutin against
colistin-induced neurotoxicity in rats. Thirty-five male Sprague Dawley rats were randomly …

Therapeutic effects of silymarin and naringin on methotrexate‐induced nephrotoxicity in rats: Biochemical evaluation of anti‐inflammatory, antiapoptotic, and …

FM Kandemir, S Kucukler, C Caglayan… - Journal of food …, 2017 - Wiley Online Library
Silymarin (SLY) and naringin (NRG) are natural flavonoids that have been reported to have
many benefits and medicinal properties. The present study was designed to investigate the …

Autophagy in human health and disease: novel therapeutic opportunities

F Giampieri, S Afrin, TY Forbes-Hernandez… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process,
through which macromolecules and cytoplasmic material are degraded into lysosomes and …

[HTML][HTML] Rutin attenuates sorafenib-induced chemoresistance and autophagy in hepatocellular carcinoma by regulating BANCR/miRNA-590-5P/OLR1 axis

M Zhou, G Zhang, J Hu, Y Zhu, H Lan… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
Rutin, the main component of Potentilla discolor Bunge, was proven to exhibit anti-tumor
properties. Sorafenib (SO) is conventionally used in chemotherapy against hepatocellular …

[HTML][HTML] Rutin ameliorates gout via reducing XOD activity, inhibiting ROS production and NLRP3 inflammasome activation in quail

H Wu, Y Wang, J Huang, Y Li, Z Lin, B Zhang - Biomedicine & …, 2023 - Elsevier
Gout is a metabolic disease affected by monosodium urate (MSU) deposition, which is
directly related to hyperuricemia. Recent reports on the prevalence and incidence of gout …

Molecular interactions between reactive oxygen species and autophagy in kidney disease

GP Kaushal, K Chandrashekar, LA Juncos - International journal of …, 2019 - mdpi.com
Reactive oxygen species (ROS) are highly reactive signaling molecules that maintain redox
homeostasis in mammalian cells. Dysregulation of redox homeostasis under pathological …

Rutin prevents cardiac oxidative stress and inflammation induced by bisphenol A and dibutyl phthalate exposure via NRF-2/NF-κB pathway

OI Oluranti, BA Alabi, OS Michael, AO Ojo, BP Fatokun - Life sciences, 2021 - Elsevier
Aim Environmental pollutants such as plastic-component substances (phthalates and
bisphenol A) that coexist in natural ecosystems have been linked to an increase in the …