The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma

LVM De Assis, J Locatelli, MC Isoldi - … et Biophysica Acta (BBA)-Reviews on …, 2014 - Elsevier
Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often
diagnosed at an advanced stage. Several players have been implicated in the development …

The pathogenesis of mesothelioma is driven by a dysregulated translatome

S Grosso, A Marini, K Gyuraszova, JV Voorde… - Nature …, 2021 - nature.com
Malignant mesothelioma (MpM) is an aggressive, invariably fatal tumour that is causally
linked with asbestos exposure. The disease primarily results from loss of tumour suppressor …

Diagnostic and therapeutic challenges of malignant pleural mesothelioma

J Moro, S Sobrero, CF Cartia, S Ceraolo, R Rapanà… - Diagnostics, 2022 - mdpi.com
Malignant pleural mesothelioma is a rare cancer characterized by a very poor prognosis.
Exposure to asbestos is the leading cause of malignant pleural mesothelioma. The …

MicroRNA-29b attenuates non-small cell lung cancer metastasis by targeting matrix metalloproteinase 2 and PTEN

H Wang, X Guan, Y Tu, S Zheng, J Long, S Li… - Journal of experimental …, 2015 - Springer
Background Our pilot study using miRNA PCR array found that miRNA-29b (miR-29b) is
differentially expressed in primary cultured CD133-positive A549 cells compared with …

[HTML][HTML] Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway

NQ Yang, XJ Luo, J Zhang, GM Wang… - American journal of …, 2016 - ncbi.nlm.nih.gov
Abstract Maternally Expressed Gene 3 (Meg3) encodes a long non-coding RNA that has
been recently shown to regulate tumorigenesis through its interaction with microRNA (miR) …

MiR-19a negatively regulated the expression of PTEN and promoted the growth of ovarian cancer cells

Y Wang, S Zhao, L Zhu, Q Zhang, Y Ren - Gene, 2018 - Elsevier
Ovarian cancer is the most lethal malignancy of the women genital tract. Exploring novel
factors involved in the development of ovarian cancer and characterizing the molecular …

KRAS mutations are associated with shortened survival in patients with epithelioid malignant pleural mesothelioma

M Vannucchi, V Pennati, C Mencaroni, C Defraia… - Cancers, 2023 - mdpi.com
Simple Summary Malignant pleural mesothelioma (MPM) is an aggressive tumor with
implacable prognosis. It commonly harbors loss-of-function mutations in BAP1, NF2 …

[HTML][HTML] The component formula of Salvia miltiorrhiza and Panax ginseng induces apoptosis and inhibits cell invasion and migration through targeting PTEN in lung …

L Bi, X Yan, Y Yang, L Qian, Y Tian, JH Mao, W Chen - Oncotarget, 2017 - ncbi.nlm.nih.gov
Lung cancer still remains the leading cause of cancer-related death worldwide. It is an
urgent need for development of novel therapeutic agents to improve current treatment of this …

[PDF][PDF] The role of microRNA in metastatic processes of non-small cell lung carcinoma.

Z Pastorkova, J Skarda, J Andel - Biomedical Papers of the …, 2016 - biomed.papers.upol.cz
Background. MicroRNAs are small non-coding one-stranded RNA molecules that play an
important role in the posttranscriptional regulation of genes. Bioinformatic predictions …

Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway

F Xu, X Gao, H Pan - Oncology Reports, 2018 - spandidos-publications.com
Lung cancer is the principal cause of cancer‑associated mortality. Pectolinarigenin (Pec)
reportedly has effective antitumor activity against certain cancer types. Phosphatase and …