Two-component systems reprogramme diverse aspects of microbial physiology in response
to environmental cues. Canonical systems are composed of a transmembrane sensor …

Bacteria in the genus Brucella are important human and veterinary pathogens. The abortion
and infertility they cause in food animals produce economic hardships in areas where the …

Perceiving environmental and internal information and reacting in adaptive ways are
essential attributes of living organisms. Two-component systems are relevant protein …

Response regulators function as the output components of two-component systems, which
couple the sensing of environmental stimuli to adaptive responses. Response regulators …

In two-component systems, the information gathered by histidine kinases (HKs) are relayed
to cognate response regulators (RRs). Thereby, the phosphoryl group of the auto …

Sensor histidine kinases are central to sensing in bacteria and in plants. They usually
contain sensor, linker, and kinase modules and the structure of many of these components is …

Brucella abortus is a class III zoonotic bacterial pathogen able to survive and replicate inside
host cells, including macrophages. Here we report a multidimensional transposon …

In scientific research, we often rely on well-established model systems to tackle important
questions. In this context, extensive characterization of specific bacterial species such as …

Two-component systems (TCS) are protein machineries that enable cells to respond to input
signals. Histidine kinases (HK) are the sensory component, transferring information toward …

The cell envelope is a multilayered structure that insulates the interior of bacterial cells from
an often chaotic outside world. Common features define the envelope across the bacterial …