[HTML][HTML] The biogenesis of lipid droplets: lipids take center stage

M Gao, X Huang, BL Song, H Yang - Progress in lipid research, 2019 - Elsevier
Lipid droplets (LDs) are multi-functional cellular organelles that store energy, and regulate
many aspects of cell physiology. However, our understanding of the biogenesis of LDs …

Adipogenesis at a glance

CE Lowe, S O'Rahilly, JJ Rochford - Journal of cell science, 2011 - journals.biologists.com
The formation of adipocytes from precursor stem cells involves a complex and highly
orchestrated programme of gene expression. Our understanding of the basic network of …

Phospholipase D: enzymology, functionality, and chemical modulation

PE Selvy, RR Lavieri, CW Lindsley, HA Brown - Chemical reviews, 2011 - ACS Publications
Phosphatidic acid (PA) is a critical phospholipid constituent in eukaryotic cell membranes,
which accounts for 1À4% of the total lipid. 1 This lipophilic glycerophospholipid has a …

The combined effect of protein hydrolysis and Lactobacillus plantarum fermentation on antioxidant activity and metabolomic profiles of quinoa beverage

FB Meng, L Zhou, JJ Li, YC Li, M Wang, LH Zou… - Food Research …, 2022 - Elsevier
Lactic acid bacteria fermentation is a commonly applied technique to produce nutritional,
functional, and organoleptic enhanced foods. In the present study, protein hydrolysis and …

PPARs and lipid ligands in inflammation and metabolism

GS Harmon, MT Lam, CK Glass - Chemical reviews, 2011 - ACS Publications
Peroxisome proliferator-activated receptors (PPARs) belong to a family of ligand-activated
nuclear receptors that includes the estrogen, thyroid hormone, and glucocorticoid receptors …

Endogenous ligands for nuclear receptors: digging deeper

M Schupp, MA Lazar - Journal of Biological Chemistry, 2010 - ASBMB
Nuclear receptors (NRs) are hormone-sensing transcription factors that translate dietary or
endocrine signals into changes in gene expression. Therefore, the adoption of orphan NRs …

The PPAR-RXR transcriptional complex in the vasculature: energy in the balance

J Plutzky - Circulation research, 2011 - Am Heart Assoc
The peroxisome proliferator-activated receptors (PPARs) and the retinoid X receptors
(RXRs) are ligand-activated transcription factors that coordinately regulate gene expression …

Aiming drug discovery at lysophosphatidic acid targets

G Tigyi - British journal of pharmacology, 2010 - Wiley Online Library
Lysophosphatidic acid (LPA, 1‐radyl‐2‐hydroxy‐sn‐glycero‐3‐phosphate) is the prototype
member of a family of lipid mediators and second messengers. LPA and its naturally …

The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

K Chakraborty, M Raundhal, BB Chen, C Morse… - Nature …, 2017 - nature.com
Bacterial pneumonia is a significant healthcare burden worldwide. Failure to resolve
inflammation after infection precipitates lung injury and an increase in morbidity and …

Potential of natural products in the inhibition of adipogenesis through regulation of PPARγ expression and/or its transcriptional activity

S Feng, L Reuss, Y Wang - Molecules, 2016 - mdpi.com
Obesity is a global health problem characterized as an increase in the mass of adipose
tissue. Adipogenesis is one of the key pathways that increases the mass of adipose tissue …