In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Abstract Gamma oscillations (30–90 Hz) in the brain are known to have an evident
relationship with many cognitive processes. Computational models are promising tools for …

The hippocampal theta rhythm plays important roles in information processing; however, the
mechanisms of its generation are not well understood. We developed a data-driven …

Background Abnormal accumulation of amyloid β 1–42 oligomers (AβO 1–42), a hallmark of
Alzheimer's disease, impairs hippocampal theta-nested gamma oscillations and long-term …

The prevailing view is that parvalbumin (PV) interneurons play modulatory roles in
emotional response through local medium spiny projection neurons (MSNs). Here, we show …

Computational models are powerful tools for exploring the properties of complex biological
systems. In neuroscience, data-driven models of neural circuits that span multiple scales are …

Gamma oscillations are believed to play a critical role in in information processing,
encoding, and retrieval. Inhibitory interneuronal network gamma (ING) oscillations may arise …

Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback
inhibition and have a key role in gamma oscillations and information processing. The …

Dendrites are essential determinants of the input-output relationship of single neurons, but
their role in network computations is not well understood. Here, we use a combination of …

As researchers develop computational models of neural systems with increasing
sophistication and scale, it is often the case that fully de novo model development is …