Exploring protein-protein interactions for the development of new analgesics
AM do Nascimento, RB Marques, AP Roldão… - Science …, 2024 - science.org
The development of new analgesics has been challenging. Candidate drugs often have
limited clinical utility due to side effects that arise because many drug targets are involved in …
limited clinical utility due to side effects that arise because many drug targets are involved in …
The role of neuropilin in bone/cartilage diseases
Z Wu, Y Wang, W Liu, M Lu, J Shi - Life Sciences, 2024 - Elsevier
Bone remodeling is the balance between osteoblasts and osteoclasts. Bone diseases such
as osteoporosis and osteoarthritis are associated with imbalanced bone remodeling …
as osteoporosis and osteoarthritis are associated with imbalanced bone remodeling …
Genetic overlap and causality between COVID-19 and multi-site chronic pain: the importance of immunity
Y Chen, P Liu, Z Zhang, Y Ye, S Yi, C Fan… - Frontiers in …, 2024 - frontiersin.org
Background The existence of chronic pain increases susceptibility to virus and is now widely
acknowledged as a prominent feature recognized as a major manifestation of long-term …
acknowledged as a prominent feature recognized as a major manifestation of long-term …
Peptidomimetic inhibitors of the VEGF-A165/NRP-1 complex obtained by modification of the C-terminal arginine
D Tymecka, P Redkiewicz, PFJ Lipiński, A Misicka - Amino Acids, 2024 - Springer
Inhibitors of the interaction between Neuropilin-1 (NRP-1) and Vascular Endothelial Growth
Factor-A165 (VEGF-A165) hold significant promise as therapeutic and diagnostic agents …
Factor-A165 (VEGF-A165) hold significant promise as therapeutic and diagnostic agents …
From SARS-CoV-2 to analgesia: harnessing the vascular endothelial growth factor A/neuropilin 1 axis for pain therapy
ER Mustafá, N Weiss - Pain, 2023 - journals.lww.com
Vascular endothelial growth factor (VEGF) encompasses a family of secreted proteins
primarily implicated in the control of angiogenesis during growth and development. The …
primarily implicated in the control of angiogenesis during growth and development. The …