Sepsis and septic shock: Pathogenesis and treatment perspectives

H Minasyan - Journal of critical care, 2017 - Elsevier
The majority of bacteremias do not develop to sepsis: bacteria are cleared from the
bloodstream. Oxygen released from erythrocytes and humoral immunity kill bacteria in the …

Respiratory transformation of nitrous oxide (N2O) to dinitrogen by Bacteria and Archaea

WG Zumft, PMH Kroneck - Advances in microbial physiology, 2006 - Elsevier
N 2 O is a potent greenhouse gas and stratospheric reactant that has been steadily on the
rise since the beginning of industrialization. It is an obligatory inorganic metabolite of …

Methylophilaceae link methanol oxidation to denitrification in freshwater lake sediment as suggested by stable isotope probing and pure culture analysis

MG Kalyuhznaya, W Martens‐Habbena… - Environmental …, 2009 - Wiley Online Library
In this work we assessed the potential for the denitrification linked to methanol consumption
in a microbial community inhabiting the top layer of the sediment of a pristine lake, Lake …

Energetics of pathogenic bacteria and opportunities for drug development

GM Cook, C Greening, K Hards, M Berney - Advances in microbial …, 2014 - Elsevier
The emergence and spread of drug-resistant pathogens and our inability to develop new
antimicrobials to overcome resistance has inspired scientists to consider new targets for …

Metabolism and virulence in Neisseria meningitidis

C Schoen, L Kischkies, J Elias… - Frontiers in cellular and …, 2014 - frontiersin.org
A longstanding question in infection biology addresses the genetic basis for invasive
behavior in commensal pathogens. A prime example for such a pathogen is Neisseria …

Ralstonia solanacearum uses inorganic nitrogen metabolism for virulence, ATP production, and detoxification in the oxygen-limited host xylem environment

BL Dalsing, AN Truchon, ET Gonzalez-Orta, AS Milling… - MBio, 2015 - Am Soc Microbiol
Genomic data predict that, in addition to oxygen, the bacterial plant pathogen Ralstonia
solanacearum can use nitrate (NO3−), nitrite (NO2−), nitric oxide (NO), and nitrous oxide …

Biochemical and genomic analysis of the denitrification pathway within the genus Neisseria

KR Barth, VM Isabella, VL Clark - Microbiology, 2009 - microbiologyresearch.org
Since Neisseria gonorrhoeae and Neisseria meningitidis are obligate human pathogens, a
comparison with commensal species of the same genus could reveal differences important …

Nitrite and nitrite reductases: from molecular mechanisms to significance in human health and disease

N Castiglione, S Rinaldo, G Giardina… - Antioxidants & redox …, 2012 - liebertpub.com
Nitrite, previously considered physiologically irrelevant and a simple end product of
endogenous nitric oxide (NO) metabolism, is now envisaged as a reservoir of NO to be …

Burden of bacterial bloodstream infections and recent advances for diagnosis

SP Costa, CM Carvalho - Pathogens and Disease, 2022 - academic.oup.com
Bloodstream infections (BSIs) and subsequent organ dysfunction (sepsis and septic shock)
are conditions that rank among the top reasons for human mortality and have a great impact …

Modeling Neisseria meningitidis metabolism: from genome to metabolic fluxes

GJE Baart, B Zomer, A de Haan, LA van der Pol… - Genome biology, 2007 - Springer
Background Neisseria meningitidis is a human pathogen that can infect diverse sites within
the human host. The major diseases caused by N. meningitidis are responsible for death …