High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

High-altitude environments provide ideal testing grounds for investigations of mechanism
and process in physiological adaptation. In vertebrates, much of our understanding of the …

The first edition of the Textbook of Medical Physiology was written by Arthur C. Guyton
almost 50 years ago. Unlike many major medical textbooks, which often have 20 or more …

The Flexible Phenotype attempts a true synthesis of physiology, behaviour, and ecology by
developing an empirical argument that describes the intimate connections between …

The aim of this review is to provide greater insight and understanding regarding the scientific
nature of cycling. Research findings are presented in a practical manner for their direct …

Skeletal muscle shows an enormous plasticity to adapt to stimuli such as contractile activity
(endurance exercise, electrical stimulation, denervation), loading conditions (resistance …

Since its first documented observation in exhausted animal muscle in the early 19th century,
the role of lactate (lactic acid) has fascinated muscle physiologists and biochemists. Initial …

Anecdotal evidence surrounding Tibetans' and Sherpas' exceptional tolerance to hypobaric
hypoxia has been recorded since the beginning of high-altitude exploration. These …

A central debate in the exercise sciences is the cause of the fatigue that develops especially
during high intensity exercise of short duration. The most popular theory holds that this form …

Studies performed over the past decade have yielded new information related to the
physiological and metabolic adjustments made in response to both shortand long-term high …