Abstract Background Deregulation of Wnt/β-catenin signaling is a hallmark of the majority of
sporadic forms of colorectal cancer and results in increased stability of the protein β-catenin …

Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer
chemotherapeutic agents. With respect to colorectal cancer (CRC), several critical mutations …

Autophagy is a cell survival mechanism by which bulk cytoplasmic material, including
soluble macromolecules and organelles, is targeted for lysosomal degradation. The role of …

The nutrient-sensing metabolite S-adenosylmethionine (SAM) controls one-carbon
metabolism by donating methyl groups to biochemical building blocks, DNA, RNA, and …

The Motin family proteins can regulate cell polarity, cell mobility, and proliferation during
embryonic development by controlling distinct signaling pathways. In this study, we …

Microvillus inclusion disease (MVID) is an autosomal recessive condition resulting in
intractable secretory diarrhea in newborns due to loss-of-function mutations in myosin Vb …

The high expression of PACAP (pituitary adenylate cyclase-activating polypeptide)-
preferring receptor PAC1 is associated with nerve injury and tumors. Our previous report (Yu …

Thickening and the subsequent invagination of the epithelium are an important initial step in
ectodermal organ development. Ikkα has been shown to play a critical role in controlling …

Biological information processing in living systems like cells, tissues and organs critically
depends on the physical interactions of molecular signaling components in time and space …

Microvillus Inclusion Disease (MVID) is an autosomal recessive condition resulting in
intractable 27 secretory diarrhea in newborns due to loss-of-function mutations in myosin Vb …