Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

Mammalian genes transcribe RNA not continuously, but in bursts. Transcriptional output can
be modulated by altering burst fraction or burst size, but how regulatory elements control …

A succession of technological advances over the past decade have enabled researchers to
chart maps of histone modifications and related chromatin structures with increasing …

Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin
structure, and genome evolution. Recent advances in genome-scale mapping of replication …

The temporal order of DNA replication (replication timing [RT]) is highly coupled with
genome architecture, but cis-elements regulating either remain elusive. We created a series …

Diet and energy metabolism affect gene expression, which influences human health and
disease. Here, we discuss the role of epigenetics as a mechanistic link between energy …

DNA replication is spatially and temporally regulated during S‐phase. DNA replication
timing is established in early‐G1‐phase at a point referred to as timing decision point …

The eukaryotic genome is replicated according to a specific spatio‐temporal programme.
However, little is known about both its molecular control and biological significance. Here …

The genome is subject to a diverse array of epigenetic modifications from DNA methylation
to histone posttranslational changes. Many of these marks are somatically stable through …