Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

In the human body, cell division and metabolism are expected to transpire uneventfully for
approximately 25 years. Then, secondary metabolism and cell damage products …

The precise neurophysiological changes prompted by meningeal lymphatic dysfunction
remain unclear. Here, we showed that inducing meningeal lymphatic vessel ablation in adult …

Global emphasis on enhancing prevention and treatment strategies necessitates an
increased understanding of the biological mechanisms of psychopathology. Plasma …

Neuroimaging evidence has suggested white matter microstructure are heavily affected in
Alzheimer's disease (AD). However, whether white matter dysfunction is localized at the …

Oxidative stress and neuroinflammation are involved in the pathogenesis of alcohol
addiction. However, little is known regarding the effect of genetic, behavioral, psychological …

Protein aggregation trends in neurodegenerative diseases are largely unmapped due to the
complex nature of protein-protein interactions and their regulatory machineries such as …

Oxidative stress is associated with white matter diffusion metrics in adults with bipolar
disorder (BD). We examined the association of single-nucleotide polymorphisms in the …

Bioenergetic homeostasis is a vital process maintaining cellular health and has primary
importance in neuronal cells due to their high energy demand markedly at synapses …

Aging is usually accompanied by a cognitive decline in quantitative reasoning and
perceptual speed, which is associated with decreased white matter volume and integrity in …