Multiple sclerosis (MS) is an autoimmune demyelinating disease and a common cause of
neurological disability in young adults. The modest heritability of MS reflects complex …

The presence or absence of anti-citrullinated peptide antibodies (ACPA) and associated
disparities in patients with rheumatoid arthritis (RA) implies disease heterogeneity with …

Human leukocyte antigen (HLA)-encoded surface molecules present antigenic peptides to T
lymphocytes and play a key role in adaptive immune responses. Besides their physiological …

The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …

Mass spectrometry (MS) based immunopeptidomics is used in several biomedical
applications including neo-epitope discovery in oncology, next-generation vaccine …

The field of neuroimmunology endorses the involvement of the adaptive immune system in
central nervous system (CNS) health, disease, and aging. While immune cell trafficking into …

Genetic susceptibility to multiple sclerosis (MS) is associated with the MHC located on
chromosome 6p21. This signal maps primarily to a 1-Mb region encompassing the HLA …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut. Genetic
association studies have identified the highly variable human leukocyte antigen (HLA) …

Multiple Sclerosis (MS) is the second cause of paraplegia among young adults, after all
types of CNS traumatic lesions. In its most frequent relapsing-remitting form, the severity of …

For more than 30 years the only genetic factor associated with susceptibility to multiple
sclerosis (MS) was the human leukocyte antigen (HLA) region. Recent advancements in …