Immunotherapies for hepatocellular carcinoma

JM Llovet, F Castet, M Heikenwalder… - Nature reviews Clinical …, 2022 - nature.com
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …

The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma

R Donne, A Lujambio - Hepatology, 2023 - journals.lww.com
The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …

The role of PI3K/AKT/mTOR signaling in hepatocellular carcinoma metabolism

LY Tian, DJ Smit, M Jücker - International Journal of Molecular Sciences, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains …

Natural killer cells and T cells in hepatocellular carcinoma and viral hepatitis: current status and perspectives for future immunotherapeutic approaches

SG Kalathil, Y Thanavala - Cells, 2021 - mdpi.com
Natural killer (NK) cells account for 25–50% of the total number of hepatic lymphocytes,
which implicates that NK cells play an important role in liver immunity. The frequencies of …

Harnessing natural killer cells for lung cancer therapy

S Ma, MA Caligiuri, J Yu - Cancer Research, 2023 - AACR
Lung cancer is the leading cause of cancer-related death worldwide. Although natural killer
(NK) cells are garnering interest as a potential anticancer therapy because they selectively …

Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma

Y Xia, ZJ Brown, H Huang, A Tsung - Cancer Medicine, 2021 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a typical inflammation‐induced cancer and displays a
complex interaction between the tumor microenvironment and tumor development. Immune …

IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells

I Terrén, V Sandá, A Amarilla-Irusta… - Frontiers in …, 2023 - frontiersin.org
Natural killer (NK) cells are lymphocytes with potent antitumor functions and, consequently,
several NK cell-based strategies have been developed for cancer immunotherapy. A …

[HTML][HTML] Modulating NK cell metabolism for cancer immunotherapy

I Terrén, A Orrantia, J Vitallé, G Astarloa-Pando… - Seminars in …, 2020 - Elsevier
Natural killer (NK) cells are lymphocytes with potent antitumor functions and, therefore,
multiple NK cell-based cancer immunotherapies have been developed and are currently …

Impending HCC diagnosis in patients with cirrhosis after HCV cure features a natural killer cell signature

SA Engelskircher, PC Chen, B Strunz, C Oltmanns… - Hepatology, 2024 - journals.lww.com
Conclusions: We show that HCV-related HCC development has profound effects on the
imprint of NK cells. Persistent co-expression of TIM-3hi and CD38+ on NK cells is an early …

Immunotherapies for hepatocellular carcinoma and intrahepatic cholangiocarcinoma: current and developing strategies

J Argemi, M Ponz-Sarvise, B Sangro - Advances in Cancer Research, 2022 - Elsevier
Liver cancer including hepatocellular carcinoma (HCC) and intrahepatic
cholangiocarcinoma (iCCA) is the third leading cause of cancer-related deaths worldwide …