Heat shock protein 90 (HSP90) is a vital chaperone protein, regulating signaling pathways
and correcting misfolded proteins in cancer cells by interacting with oncogenic client …

The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are
involved in myriad cellular processes. Their distribution in various cellular compartments …

The 90-kDa heat shock protein (Hsp90) is a molecular chaperone that ensures cellular
proteostasis by maintaining the folding, stabilization, activation, and degradation of over 400 …

Glucose-regulated protein 94 is the HSP90-like protein in the lumen of the endoplasmic
reticulum and therefore it chaperones secreted and membrane proteins. It has essential …

Objective: Vascular calcification is common among aging populations and mediated by
vascular smooth muscle cells (VSMCs). The endoplasmic reticulum (ER) is involved in …

The ubiquitous molecular chaperone Hsp90 makes up 1–2% of cytosolic proteins and is
required for viability in eukaryotes. Hsp90 affects the folding and activation of a wide variety …

Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential
role in many cellular processes including cell cycle control, cell survival, hormone and other …

A system of endoplasmic reticulum (ER) chaperones has evolved to optimize the output of
properly folded secretory and membrane proteins. An important player in this network is …

Ca2+ is an important intracellular messenger affecting many diverse processes. In
eukaryotic cells, Ca2+ storage is achieved within specific intracellular organelles, especially …

The endoplasmic reticulum is a major compartment of protein biogenesis in the cell,
dedicated to production of secretory, membrane and organelle proteins. The secretome has …