Targeting disorders in unstructured and structured proteins in various diseases

S Choudhary, M Lopus, RV Hosur - Biophysical Chemistry, 2022 - Elsevier
Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs)
are proteins and protein segments that usually do not acquire well-defined folded structures …

Hesperidin ameliorates sarcopenia through the regulation of inflammaging and the AKT/mTOR/FoxO3a signaling pathway in 22–26-month-old mice

HJ Oh, H Jin, BY Lee - Cells, 2023 - mdpi.com
Faced with a globally aging society, the maintenance of health and quality of life in older
people is very important. The age-related loss of muscle mass and strength, known as …

Molecular insights into the phase transition of lysozyme into amyloid nanostructures: Implications of therapeutic strategies in diverse pathological conditions

S Roy, VR Srinivasan, S Arunagiri, N Mishra… - Advances in Colloid and …, 2024 - Elsevier
Lysozyme, a well-known bacteriolytic enzyme, exhibits a fascinating yet complex behavior
when it comes to protein aggregation. Under certain conditions, this enzyme undergoes …

Lysozyme–luteolin binding: molecular insights into the complexation process and the inhibitory effects of luteolin towards protein modification

S Das, S Pahari, S Sarmah, MA Rohman… - Physical Chemistry …, 2019 - pubs.rsc.org
In the proposed work, the complexation of bioactive flavonoid luteolin with hen egg white
lysozyme (HEWL) along with its inhibitory influence on HEWL modification has been …

Effect of 1-methyl-3-octyleimmidazolium chloride on the stability and activity of lysozyme: a spectroscopic and molecular dynamics studies

M Kumari, N Dohare, N Maurya… - Journal of …, 2017 - Taylor & Francis
Herein, the binding of 1-methyl-3-octylimidazolium chloride [OMIM][Cl] ionic liquid with hen
egg white lysozyme (HEWL) has been studied using fluorescence, time resolved …

Insight into the binding behavior of ceritinib on human α-1 acid glycoprotein: Multi-spectroscopic and molecular modeling approaches

BL Wang, SB Kou, ZY Lin, JH Shi - … Acta Part A: Molecular and Biomolecular …, 2020 - Elsevier
Ceritinib is a second-generation anaplastic lymphoma kinase (ALK) inhibitor for mainly
treating non-small cell lung cancer (NSCLC). This investigation focused on to clarify in detail …

Comparative effect of cationic gemini surfactant and its monomeric counterpart on the conformational stability and activity of lysozyme

T Sharma, N Dohare, M Kumari, UK Singh, AB Khan… - Rsc Advances, 2017 - pubs.rsc.org
Protein interactions with surfactants are dependent on their physiochemical properties. The
effect of cationic gemini surfactant hexanediyl-α, ω-bis-(N-(2-hydroxyethyl)-N …

Mechanistic insights into monomer level prevention of amyloid aggregation of lysozyme by glycyrrhizic acid

SA Muthu, R Sharma, A Qureshi, S Parvez… - International Journal of …, 2023 - Elsevier
As the primary bioactive compound of glycyrrhiza rhizome, the triterpene glycoside
conjugate Glycyrrhizic acid (GA) has demonstrated neuroprotective effects in vivo. This study …

[HTML][HTML] Characterizing the binding interaction of fungicide boscalid with bovine serum albumin (BSA): a spectroscopic study in combination with molecular docking …

YY Lou, KL Zhou, JH Shi, DQ Pan - Journal of Photochemistry and …, 2017 - Elsevier
Boscalid, a carboxamide fungicide, is used in the treatment of grey mould and powdery
mildew, widely applied to a variety of crops and fruits such as rice, wheat, grapes and pears …

[HTML][HTML] Exploring the non-covalent binding behaviours of 7-hydroxyflavone and 3-hydroxyflavone with hen egg white lysozyme: multi-spectroscopic and molecular …

S Das, MA Rohman, AS Roy - Journal of Photochemistry and Photobiology …, 2018 - Elsevier
The interactions of bio-active flavonoids, 7-hydroxyflavone (7HF) and 3-hydroxyflavone
(3HF) with hen egg white lysozyme (HEWL) have been established using differential …