Progress in structure, synthesis and biological activity of natural cephalotane diterpenoids

C Jiang, J Xue, Y Yuan, Y Li, C Zhao, Q Jing, X Zhang… - Phytochemistry, 2021 - Elsevier
The Cephalotaxus genus is well-known owing to the numerous complex, biologically
relevant natural products that can be obtained from its constituent species. The successful …

Asymmetric total syntheses of cephalotane-type diterpenoids cephanolides A–D

Z Qing, P Mao, T Wang, H Zhai - Journal of the American …, 2022 - ACS Publications
Cephanolides A–D are cephalotane-type diterpenoids featuring a novel 6/6/6/5 tetracyclic
core embedded with a bridged δ-lactone. The asymmetric and divergent total syntheses of …

Total Synthesis of (±)-Cephanolides B and C via a Palladium-Catalyzed Cascade Cyclization and Late-Stage sp3 C–H Bond Oxidation

L Xu, C Wang, Z Gao, YM Zhao - Journal of the American …, 2018 - ACS Publications
Herein, we report the first total syntheses of complex cephalotaxus diterpenoids cephanolide
B and C from commercially available 5-bromo-2-methylanisole. Key to the success of this …

Functional Characterization and Cyclization Mechanism of a Diterpene Synthase Catalyzing the Skeleton Formation of Cephalotane‐Type Diterpenoids

C Li, S Wang, X Yin, A Guo, K Xie, D Chen… - Angewandte …, 2023 - Wiley Online Library
CsCTS, a new diterpene synthase from Cephalotaxus sinensis responsible for forming
cephalotene, the core skeleton of cephalotane‐type diterpenoids with a highly rigid 6/6/5/7 …

Asymmetric total synthesis of (+)‐Mannolide C

Q Ao, HJ Zhang, J Zheng, X Chen… - Angewandte Chemie …, 2021 - Wiley Online Library
Mannolide C is a complex hexacyclic C20 cephalotane‐type diterpenoid featuring a highly
strained 7/6/6/5 tetracyclic core containing eight consecutive stereocenters and two bridging …

Total synthesis of (+)‐3‐Deoxyfortalpinoid F,(+)‐Fortalpinoid A, and (+)‐Cephinoid H

Z Ren, Z Sun, Y Li, X Fan, M Dai… - Angewandte Chemie …, 2021 - Wiley Online Library
Deoxyfortalpinoid F, fortalpinoid A, and cephinoid H are members of the Cephalotaxus
diterpenoids class of natural products, which feature diverse chemical structures and …

Total Synthesis of the Diterpenoid (+)‐Harringtonolide

HJ Zhang, L Hu, Z Ma, R Li, Z Zhang… - Angewandte Chemie …, 2016 - Wiley Online Library
Described herein is the first asymmetric total synthesis of (+)‐harringtonolide, a natural
diterpenoid with an unusual tropone imbedded in a cagelike framework. The key …

17-nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei

ZP Ge, HC Liu, GC Wang, QF Liu, CH Xu… - Journal of natural …, 2019 - ACS Publications
Seventeen new 17-nor-cephalotane-type diterpenoids, fortalpinoids A–Q (1–17), were
isolated from the seeds of Cephalotaxus fortunei var. alpine. Compound 12 represents the …

Diterpenoids from Cephalotaxus fortunei var. alpina and their cytotoxic activity

Y Li, Y Wang, Z Shao, C Zhao, Q Jing, D Li, B Lin… - Bioorganic …, 2020 - Elsevier
Abstract Cephafortunoids A–D (1–4), four new compounds, together with ten known ones (5–
14), were isolated from the branches and leaves of Cephalotaxus fortunei var. alpina. 1 and …

Evaluation of a Cascade Cyclization Approach Toward Harringtonolide

CSH Magnani, T Pinkert, TJ Maimone - Tetrahedron, 2024 - Elsevier
An account of synthetic work directed toward the total synthesis of the cytotoxic cephalotaxus
norditerpenoid, harringtonolide, is disclosed. An initial Lewis Acid-catalyzed Diels-Alder/Ene …