Targeting protein self-association in drug design
L Thabault, M Liberelle, R Frédérick - Drug Discovery Today, 2021 - Elsevier
Highlights•Homomeric interfaces are a pool of potential allosteric sites for challenging
targets.•Homomeric disruption can lead to target degradation and sub-stoichiometric …
targets.•Homomeric disruption can lead to target degradation and sub-stoichiometric …
Ligand-based pharmacophore modeling of TNF-α to design novel inhibitors using virtual screening and molecular dynamics
Tumor necrosis factor-α (TNF-α) is one of the promising targets for treating inflammatory
(Crohn disease, psoriasis, psoriatic arthritis, rheumatoid arthritis) and various other …
(Crohn disease, psoriasis, psoriatic arthritis, rheumatoid arthritis) and various other …
Di-sulfide containing cell penetrating peptides and methods of making and using thereof
10,501,496 B2 10,626,147 B2 10,738,093 B2 2002/0035243 A1 2002/0120100 Al
2003/0032594 Al 2004/0014669 A1 2007/0041904 Al 2010/0292148 A1 2014/0294942 A1 …
2003/0032594 Al 2004/0014669 A1 2007/0041904 Al 2010/0292148 A1 2014/0294942 A1 …
Tumor necrosis factor-α trimer disassembly and inactivation via peptide-small molecule synergy
JW Checco, GA Eddinger, NJ Rettko… - ACS chemical …, 2020 - ACS Publications
Aberrant signaling by tumor necrosis factor-α (TNFα) is associated with inflammatory
diseases that can be treated with engineered proteins that inhibit binding of this cytokine to …
diseases that can be treated with engineered proteins that inhibit binding of this cytokine to …
Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof
Srinivas et al. Biaryl amino acid templates in place of D-Pro-L-Pro in cyclic beta-hairpin
cationic antimicrobial peptidemimetics. Organic and Biomolecular Chemistry. vol. 5, pp …
cationic antimicrobial peptidemimetics. Organic and Biomolecular Chemistry. vol. 5, pp …
Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha
D Pei - US Patent 10,913,773, 2021 - Google Patents
Anticachexin C1 inhibits the TNFa-TNFa receptor interac tion. In this work, analogs of
anticachexin C1 are disclosed. The resulting bicyclic peptides inhibit TNFa TNFa-induced …
anticachexin C1 are disclosed. The resulting bicyclic peptides inhibit TNFa TNFa-induced …
[PDF][PDF] Targeting proteins self-association in drug design
R Frédérick - dial.uclouvain.be
Protein self-association is a universal phenomenon essential for stability and molecular
recognition. Disrupting constitutive homomers constitutes an original and emerging strategy …
recognition. Disrupting constitutive homomers constitutes an original and emerging strategy …
Di-sulfide containing cell penetrating peptides and methods of making and using thereof
US11878046B2 - Di-sulfide containing cell penetrating peptides and methods of making and
using thereof - Google Patents US11878046B2 - Di-sulfide containing cell penetrating …
using thereof - Google Patents US11878046B2 - Di-sulfide containing cell penetrating …
Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha
D Pei - US Patent 11,859,019, 2024 - Google Patents
2021-01-12 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Cyclic cell-penetrating peptides with one or more hydrophobic residues
D Pei - US Patent 11,987,647, 2024 - Google Patents
2023-01-09 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …