G-quadruplexes at telomeres: friend or foe?

TM Bryan - Molecules, 2020 - mdpi.com
Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

Transcription–replication conflicts: how they occur and how they are resolved

T García-Muse, A Aguilera - Nature reviews Molecular cell biology, 2016 - nature.com
The frequent occurrence of transcription and DNA replication in cells results in many
encounters, and thus conflicts, between the transcription and replication machineries. These …

Chromosome Duplication in Saccharomyces cerevisiae

SP Bell, K Labib - Genetics, 2016 - academic.oup.com
The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Pif1 family helicases suppress genome instability at G-quadruplex motifs

K Paeschke, ML Bochman, PD Garcia, P Cejka… - Nature, 2013 - nature.com
Abstract The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1
DNA helicase family, which is conserved from bacteria to humans. Here we show that …

Maintaining genome stability at the replication fork

D Branzei, M Foiani - Nature reviews Molecular cell biology, 2010 - nature.com
Aberrant DNA replication is a major source of the mutations and chromosome
rearrangements that are associated with pathological disorders. When replication is …

Structure and mechanism of helicases and nucleic acid translocases

MR Singleton, MS Dillingham, DB Wigley - Annu. Rev. Biochem., 2007 - annualreviews.org
Helicases and translocases are a ubiquitous, highly diverse group of proteins that perform
an extraordinary variety of functions in cells. Consequently, this review sets out to define a …

Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End

RJ Wellinger, VA Zakian - Genetics, 2012 - academic.oup.com
The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Replication fork stalling at natural impediments

EV Mirkin, SM Mirkin - Microbiology and molecular biology …, 2007 - Am Soc Microbiol
Accurate and complete replication of the genome in every cell division is a prerequisite of
genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely …

Telomere replication: solving multiple end replication problems

E Bonnell, E Pasquier, RJ Wellinger - Frontiers in Cell and …, 2021 - frontiersin.org
Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …

How telomeres are replicated

E Gilson, V Géli - Nature reviews Molecular cell biology, 2007 - nature.com
The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …