Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting
treatment modality that holds the promise of expanding the therapeutic index for nearly any …

Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy.
Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic …

Radiation exposures at ultrahigh dose rates (UHDRs) at several orders of magnitude greater
than in current clinical radiotherapy (RT) have been shown to manifest differential …

In their seminal paper from 2014, Fauvadon et al. coined the term FLASH irradiation to
describe ultra‐high‐dose rate irradiation with dose rates greater than 40 Gy/s, which results …

The biological effects of radiation dose to organs at risk surrounding tumor target volumes
are a major dose-limiting constraint in radiotherapy. This can mean that the tumor cannot be …

In studies of electron and proton radiotherapy, ultrahigh dose rates of FLASH radiotherapy
appear to produce fewer toxicities than standard dose rates while maintaining local tumor …

FLASH radiotherapy (RT) is a novel technique in which the ultrahigh dose rate (UHDR)(≥
40 Gy/s) is delivered to the entire treatment volume. Recent outcomes of in vivo studies …

A reemergence of research implementing radiation delivery at ultra-high dose rates
(UHDRs) has triggered intense interest in the radiation sciences and has opened a new field …

Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …

Abstract Treatment of advanced ovarian cancer using PD-1/PD-L1 immune checkpoint
blockade shows promise; however, current clinical trials are limited by modest response …