Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

This Review explores the dynamic behavior of water within nanopores and biological
channels in lipid bilayer membranes. We focus on molecular simulation studies, alongside …

Transmembrane channels and pores have key roles in fundamental biological processes
and in biotechnological applications such as DNA nanopore sequencing,–, resulting in …

The amino-acid sequence of a protein encodes information on its three-dimensional
structure and specific functionality. De novo design has emerged as a method to manipulate …

Membrane nanopores are key for molecular transport in biology, portable DNA sequencing,,–
, label-free single-molecule analysis,,,,,,,,–and nanomedicine. Transport traditionally relies …

Abstract Information in proteins flows from sequence to structure to function, with each step
causally driven by the preceding one. Protein design is founded on inverting this process …

Controlled transport of biomolecules across lipid bilayer membranes is of profound
significance in biological processes. In cells, cargo exchange is mediated by dedicated …

Sequencing of nucleic acids with nanopores has emerged as a powerful tool offering rapid
readout, high accuracy, low cost and portability. This label-free method for sequencing at the …

The design of peptides that assemble in membranes to form functional ion channels is
challenging. Specifically, hydrophobic interactions must be designed between the peptides …

Despite the astonishing diversity and complexity of living systems, they all share five
common hallmarks: compartmentalization, growth and division, information processing …