Our expanding expertise in peripheral nerve regeneration and soft tissue reconstruction is
enabling the development of novel innervated tissue constructs that can be combined with …

Critical-sized peripheral nerve injuries pose a significant clinical challenge and lead to
functional loss and disability. Current regeneration strategies, including autografts, synthetic …

Peripheral neurons are heterogeneous and functionally diverse, but all share the capability
to switch to a pro-regenerative state after nerve injury. Despite the assumption that the injury …

Introduction Motor neurons differ from sensory neurons in aspects including origins and
surrounding environment. Understanding the similarities and differences in molecular …

Locomotor recovery after spinal cord injury (SCI) remains an unmet challenge. Nerve
transfer (NT), the connection of a functional/expendable peripheral nerve to a paralyzed …

Functional reconstruction after peripheral nerve injury depends on the ability of the
regenerated sensory and motor axons to re-innervate the suitable target organs. Therefore …

To restore function after nerve injury, axons must regenerate from the injury site to the
periphery, then reinnervate appropriate end organs when they arrive. Only 10% of adults …

Introduction The epidermal growth factor receptor (EGFR; ErbB1), a membrane bound
receptor tyrosine kinase, is hypothesized to have an inhibitory influence on peripheral nerve …

To maximally utilize the peripheral nervous system for prosthetic control, it is necessary to
first understand the compounded errors induced by amputated physiology before …

Peripheral nerve injuries affect millions worldwide, causing debilitating sensory and motor
deficits that can persist for extended periods. Due to slow axonal regeneration and impaired …