Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype?

D Endres, TA Pollak, K Bechter, D Denzel… - Translational …, 2022 - nature.com
Obsessive-compulsive disorder (OCD) is a highly disabling mental illness that can be
divided into frequent primary and rarer organic secondary forms. Its association with …

Post-infectious autoimmune disorders: Sydenham's chorea, PANDAS and beyond

KA Williams, SE Swedo - Brain research, 2015 - Elsevier
Infections, and the resulting immune response to these infections, have recently received
increased recognition as pathogenic mechanisms for neuropsychiatric disorders …

Clinical management of pediatric acute-onset neuropsychiatric syndrome: part II—use of immunomodulatory therapies

J Frankovich, S Swedo, T Murphy, RC Dale… - Journal of child and …, 2017 - liebertpub.com
Abstract Introduction: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a
clinically heterogeneous disorder with a number of different etiologies and disease …

Diagnostic approach to pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS): a narrative review of literature data

A Prato, M Gulisano, M Scerbo, R Barone… - Frontiers in …, 2021 - frontiersin.org
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections
(PANDAS) are clinical conditions characterized by the sudden onset of obsessive …

The Immunobiology of Tourette's Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus, and Related Disorders: A Way Forward

TK Murphy, R Kurlan, J Leckman - Journal of child and adolescent …, 2010 - liebertpub.com
Obsessive-compulsive disorder (OCD) and related conditions including Tourette's disorder
(TD) are chronic, relapsing disorders of unknown etiology associated with marked …

Characterization of the pediatric acute-onset neuropsychiatric syndrome phenotype

TK Murphy, PD Patel, JF McGuire, A Kennel… - Journal of child and …, 2015 - liebertpub.com
Objective: Pediatric acute-onset neuropsychiatric syndrome (PANS) is a subtype of
obsessive compulsive disorder (OCD) marked by an abrupt onset or exacerbation of …

Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders …

K Yaddanapudi, M Hornig, R Serge, J De Miranda… - Molecular …, 2010 - nature.com
Streptococcal infections can induce obsessive-compulsive and tic disorders. In children, this
syndrome, frequently associated with disturbances in attention, learning and mood, has …

Moving from PANDAS to CANS

HS Singer, DL Gilbert, DS Wolf, JW Mink… - The Journal of …, 2012 - jpeds.com
Harvey S. Singer, MD1, Donald L. Gilbert, MD2, David S. Wolf, MD, PhD1, Jonathan W.
Mink, MD, PhD3, and Roger Kurlan, MD4 Encountering a previously healthy child with the …

[HTML][HTML] Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS): an evolving concept

A Macerollo, D Martino - Tremor and other hyperkinetic movements, 2013 - ncbi.nlm.nih.gov
Pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections
(PANDAS) originated from the observational work of Swedo and collaborators, who …

PANDAS/PANS in the COVID-19 age: autoimmunity and Epstein–Barr virus reactivation as trigger agents?

S Pallanti, M Di Ponzio - Children, 2023 - mdpi.com
COVID-19 impacted the entire world's population, frequently resulting in long-lasting
neuropsychiatric complications. Furthermore, social distancing, lockdowns and fear for one's …