Whole blood, as one of the most significant biological fluids, provides critical information for
health management and disease monitoring. Over the past 10 years, advances in …

Nucleic acid aptamers are single stranded DNA or RNA sequences that specifically bind a
cognate ligand. In addition to their widespread use as stand-alone affinity binding reagents …

The availability of sensors able to rapidly detect SARS-CoV-2 directly in biological fluids in a
single step would allow performing massive diagnostic testing to track in real time and …

The development of a technology capable of tracking the levels of drugs, metabolites, and
biomarkers in the body continuously and in real time would advance our understanding of …

We have designed programmable DNA-based nanoswitches whose closing/opening can be
triggered over specific different pH windows. These nanoswitches form an intramolecular …

Small molecules play a major role in the human body and as drugs, toxins, and chemicals.
Tools to detect and quantify them are therefore in high demand. This review will give an …

Aptamers, including DNA, RNA and peptide aptamers, are a group of promising recognition
units that can specifically bind to target molecules and cells. Due to their excellent specificity …

Background Fluorescent silica nanoparticles have been extensively utilised in a broad
range of biological applications and are facilitated by their predictable, well-understood …

It has been almost 30 years since the invention of Systematic Evolution of Ligands by
Exponential Enrichment (SELEX) methodology and the description of the first aptamers. In …

Aptamers that undergo conformational changes upon small-molecule recognition have been
shown to gate the ionic flux through nanopores by rearranging the charge density within the …