Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that
expand during cancer, inflammation and infection, and that have a remarkable ability to …

Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and
pathological processes. The last decade has witnessed major advances in dissecting NO …

Epidermal growth factor receptor (EGFR) exists in the nucleus of highly proliferative cells
where it functions as a transcription factor. Although EGFR has transactivational activity, it …

Reactive oxygen species (ROS) are formed in mammalian cells as a consequence of
aerobic respiration. Despite multiple conserved redox modulating systems, a given …

Melanoma is a highly aggressive cancer with the poorest prognosis, representing the
deadliest form of skin cancer. Activating mutations in BRAF are the most frequent genetic …

Among the biopolymers, melanins are unique in many respects. The other essential
biopolymers–proteins, nucleic acids, and carbohydrates–are chemically well characterized; …

Cancer immunotherapy often depends on recognition of peptide epitopes by cytotoxic T
lymphocytes (CTLs). The tumor microenvironment (TME) is enriched for peroxynitrite (PNT) …

Recent studies conducted with various molecular, cellular and whole animal models have
revealed that leaf extracts of Ginkgo biloba may have anticancer (chemopreventive) …

Inflammation is a facilitating process for multiple cancer types. It is believed to affect cancer
development and progression through several etiologic pathways, including increased …

The development of cancer cell resistance to various cytotoxic stimuli continues to be a
major challenge in oncology and novel therapeutic approaches are urgently needed. Nitric …