Malaria is a major killer of children worldwide and the strongest known force for evolutionary
selection in the recent history of the human genome. The past decade has seen growing …

Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

The high mortality and widespread impact of malaria have resulted in this disease being the
strongest evolutionary selective force in recent human history, and genes that confer …

Maintaining the correct number of healthy red blood cells (RBCs) is critical for proper
oxygenation of tissues throughout the body. Therefore, RBC homeostasis is a tightly …

To estimate the burden of malarial disease, and evaluate the likely effects of control
strategies, requires reliable predictions of malaria transmission intensity. It has long been …

The optimal outcome of a malaria infection is that parasitized cells are killed and degraded
without inducing significant pathology. Since much of the pathology of malaria infection can …

Background Malaria transmission has recently fallen in many parts of Africa, but systematic
descriptions of infection and disease across all age groups are rare. Here, an …

Previous interethnic comparative studies on the susceptibility to malaria performed in West
Africa showed that Fulani are more resistant to Plasmodium falciparum malaria than are …

Host responses to infection with the malaria parasite Plasmodium falciparum vary among
individuals for reasons that are poorly understood. Here we reveal metabolic perturbations …